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Combivent contains ipratropium bromide/salbutamol. It is a combination drug used to treat chronic obstructive pulmonary disease. It is taken by inhalation. It may be used through a nebulizer or a spacer. Used as prescribed.

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Combivent is a combination of two bronchodilators that are used to prevent bronchospasm in people with chronic obstructive pulmonary disease (COPD).

When is it used?

The inhaler is used to treat bronchospastic syndrome in patients with COPD and bronchial asthma.

How does it work?

This combination drug has a pronounced bronchodilator effect due to the action of ipratropium bromide and salbutamol. The medicine works to open your airways.

How to use a Combivent inhaler?

The drug is administered by inhalation using nebulizer inhalers or a system for non-invasive ventilation of the lungs in the mode of positive airway pressure.

For adults (including elderly patients) and children over 12 years of age, the drug is used 3-4 times a day in the form of inhalation using a nebulizer.

The technique of using the inhaler:

  1. Prepare the nebulizer according to the manufacturer’s instructions;
  2. Separate the ampoule with sterile solution from the unit – for this, turn and pull it;
  3. Hold the ampoule with the cap vertically upwards and break off the cap;
  4. Squeeze the solution into the nebulizer reservoir;
  5. Use the nebulizer according to the manufacturer’s instructions.

The solution remaining unused in the nebulizer chamber should be discarded. Wash the nebulizer thoroughly.


Do not use Combivent inhaler in the following conditions:

  • hypertrophic obstructive cardiomyopathy;
  • tachyarrhythmia;
  • I trimester of pregnancy;
  • children under 12 years;
  • hypersensitivity to albuterol, ipratropium bromide, atropine or their derivatives.

With caution: angle-closure glaucoma, obstruction of the urinary tract (including against the background of prostatic hyperplasia), pronounced organic diseases of the cardiovascular system, pheochromocytoma, hyperthyroidism, insufficiently controlled diabetes mellitus, cystic fibrosis, recent myocardial infarction, II and III trimesters pregnancy, lactation (breastfeeding).

Side effects

In rare cases, the medicine can cause the following adverse reactions:

  • Respiratory system: irritation of the bronchi, nasal congestion, stridor, paradoxical bronchospasm;
  • Digestive system: nausea, dry mouth or drooling, taste perversion, diarrhea, vomiting;
  • Nervous system: headache, dizziness, excessive fatigue, nervousness, paresthesia, tremor, insomnia, impaired coordination of movements, weakness;
  • CNS: increased blood pressure, tachycardia, cardialgia, a decrease in blood pressure;
  • Urinary system: dysuria;
  • Senses: if it gets into the eyes – acute pain in the eye, impaired visual acuity, conjunctival hyperemia;
  • Allergic reactions: angioedema of the tongue, lips, face, skin rash (including urticaria), laryngospasm, bronchospasm, itching;
  • Others: dysphonia, arthralgia, alopecia.

Interaction with other drugs

Avoid using Combivent with any of the following drugs:

  • beta-adrenostimulants and xanthine derivatives (theophylline);
  • central nervous system stimulants, thyroid hormones;
  • glycosidic intoxication;
  • antihypertensive drugs, nitrates;
  • drugs for inhalation anesthesia and levodopa;
  • MAO inhibitors and tricyclic antidepressants;
  • anticholinergic drugs;
  • diuretics and glucocorticoids.

Pregnancy and breastfeeding

It is not recommended to use the drug in the II and III trimesters of pregnancy and during breastfeeding, except in cases where the expected benefit to the mother outweighs any possible risk to the fetus and baby. The medicine is contraindicated in the first trimester of pregnancy.


An overdose of ipratropium bromide is unlikely to occur due to low systemic absorption after inhalation or ingestion, therefore all symptoms of an overdose are mainly associated with the systemic effect of albuterol. Symptoms of an albuterol overdose may include headache, nausea, vomiting, angina pectoris, arterial hypertension, arterial hypotension, hypokalemia, hyperglycemia, tachycardia, arrhythmia, chest pain, tremors, flushing, anxiety, hallucinations, and dizziness.

Treatment is symptomatic.

Special instructions

In order to avoid overdose, it is not recommended to exceed the maximum permissible daily dose.

If paradoxical bronchospasm occurs, the use of Combivent should be stopped immediately. Bronchospasm may be associated with the transition to a new vial of the drug.

Avoid contact with eyes.