$1.35 per pill


Mircette is a birth control drug that contains desogestrel/ethinyl estradiol. It is applied to suppress ovulation and as a result an unwanted pregnancy. The drug is taken for 28 days without interruptions. It can treat acne.

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Mircette contributes to a decrease in serum concentrations of follicle-stimulating and luteinizing hormone, suppresses ovulation, increases the viscosity of the cervical secretion, disrupts the movement of sperm through the fallopian tube. It also causes endometrial restructuring, which makes it difficult for a fertilized egg to attach to the fallopian tube. Desogestrel Fast and complete absorption, bioavailability – 70%. It almost completely binds to plasma proteins. It is rapidly metabolized in the intestinal wall and in the liver to form an active metabolite (etonogestrel). The half-life is 30 hours. It is excreted by the kidneys and through the gastrointestinal tract. Ethinylestradiol It is rapidly and completely absorbed from the gastrointestinal tract. The maximum concentration in the blood serum is reached in 1-2 hours, bioavailability is 60%. It binds to plasma proteins by 97.5%. It is metabolized in the liver and intestines to etonogestrel. The half-life is 24 hours. It is eliminated by the kidneys by 45% and through the gastrointestinal tract by 30%. The half-life of metabolites is approximately 1 day.




  • Venous or arterial thrombosis;
  • Triggers of thrombosis (including transient attack of ischemic heart disease, angina pectoris);
  • The presence of severe or multiple risk factors for venous or arterial thrombosis (including arterial hypertension with arterial pressure of 160/100 mm Hg and above);
  • Thromboembolism;
  • Pulmonary embolism;
  • Pancreatitis;
  • Hormone-dependent malignant neoplasms of the genitals or mammary glands;
  • Vaginal bleeding of unknown etiology;
  • Pregnancy, breastfeeding;
  • Migraine;
  • Smoking over the age of 35 (more than 15 cigarettes per day);
  • Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
  • Hypersensitivity;
  • Diabetes;
  • Severe liver disease;
  • Liver tumors.

Take Micrette with caution in the following cases: diseases of the gallbladder and liver; depression; epilepsy; ulcerative colitis; tuberculosis; teenage years; uterine fibroids; age over 35; a family history of thromboembolic diseases (venous or arterial thrombosis/thromboembolism in brothers, sisters or parents at a relatively early age); obesity; dyslipoproteinemia; arterial hypertension; valvular heart disease; atrial fibrillation; prolonged immobilization; extensive surgical intervention; surgery on the lower limbs; severe injury; phlebeurysm; superficial thrombophlebitis; postpartum period; changes in biochemical parameters, which may be markers of congenital or acquired predisposition to venous or arterial thrombosis; systemic lupus erythematosus; hemolytic uremic syndrome; sickle cell anemia.

Pregnancy and lactation

FDA category – X. If pregnancy occurs, the drug should be discontinued. The drug can affect lactation, since combined oral contraceptives reduce the amount and change the composition of breast milk. Therefore, the drug is not recommended for use until the breastfeeding mother completely stops breastfeeding. Small amounts of contraceptive steroids and/or their metabolic products may be excreted in breast milk.

Mode of administration and dosage

Micrette birth control pills should be taken orally in the order indicated on the package, at approximately the same time every day, with a little water if necessary. Orally, 1 tablet per day from the first day of the cycle. Take the drug for 28 days without breaks.

Side effects

  • The immune systems: hypersensitivity.
  • The side of metabolism and nutrition: an increase in body weight, fluid retention, rarely – a decrease in body weight.
  • The nervous system: headache, migraine, decreased libido, depression, mood swings, chorea, sometimes – increased libido.
  • The side of the organ of vision: intolerance to contact lenses.
  • The digestive system: nausea, vomiting, abdominal pain, diarrhea, ulcerative colitis, cholelithiasis, Crohn’s disease.
  • Skin and subcutaneous tissue disorders: skin rash, urticaria, herpes, erythema nodosum, erythema multiforme, chloasma.
  • The reproductive system: chest pain, breast tenderness, breast enlargement, vaginal secretions, breast secretions, intermenstrual bleeding.
  • Others: thrombosis / thromboembolism, increased blood pressure, porphyria, hearing loss.


The symptoms of an overdose are vomiting, nausea, in young girls – bloody secretions from the vagina. Treatment is symptomatic. No severe complications were found with a drug overdose.


Interaction between oral contraceptives and other drugs can lead to acyclic bleeding and/or decreased contraceptive effectiveness.

  • Drugs that induce microsomal liver enzymes (especially barbiturates, carbamazepine, griseofulvin, phenytoin, primidone, rifabutin, rifampicin) – a decrease in the activity of oral contraceptives.
  • Amoxicillin, benzylpenicillin, doxycycline, tetracycline, ampicillin – reduce the drug effectiveness.
  • Anticoagulants – a change in their activity.
  • Atorvastatin – an increase in the concentration of estrogen.
  • Ascorbic acid, paracetamol – an increase in the concentration of estrogen (possibly associated with inhibition of conjugation).
  • Sugar-lowering drugs (insulin, drugs taken by mouth) – an increase in glucose tolerance, especially in patients with diabetes.
  • Benzodiazepines, caffeine – inhibiting their metabolism.
  • Hepatotoxic drugs – an increase in toxicity due to the activation of hepatic blood flow by estrogens.
  • Glucocorticoids – a decrease in their metabolism, an increase in the synthesis of transcortin.
  • Clofibrate – a decrease in its effectiveness.
  • Smoking – a possible decrease in the concentration of estrogen (induction of microsomal liver enzymes), an increase in the risk of developing cardiovascular diseases.
  • Ritonavir – a decrease in the concentration of estrogen.
  • Tamoxifen – a decrease in its antiestrogenic activity.
  • Tricyclic antidepressants, antipsychotics – an increase in the risk of movement disorders, chorea (rarely), an increased risk of an increase in the concentration of antidepressants.
  • Cyclosporine – an increase in its plasma concentration.